Izidakamizwa ze-antiticoagulants zenzelwe ukunciphisa i- blood clotting ngokunciphisa ukubunjwa kwe-fibrin. Esi siphumo sithintela ukwakheka kwegazi. Isilwanyana sisetyenziswe kwisifo sesibini kunye ne-arhente yokukhusela. Amalungiselelo e-Antikoagulant anokufumaneka kwiipilisi, njengama-injections okanye amafutha. Ikhetho lokugqibela liqhelekileyo. Kule meko, ngohlobo luni kunye nobungakanani kubalulekile ukuba kuthathe le nto, yinto engcali ekufuneka imisele, ngaphandle koko iyeza lingazibangeli nje ukulimaza, kodwa zibangele iingxaki ezinzulu.
Ama-Anticoagulants ahlukaniswe ngamalungiselelo enkqubo ngqo kunye ngqo. Umehluko omkhulu phakathi kwamaqela amabini yindlela abavimbela ngayo ukubunjwa kwe-thrombi. Kwakhona kubalulekile ukuba amalungiselelo anxulumene nama-antiticoagulants of different types.
AmaAnticoagulants of action ngqo
Ukulungiselela ama-anticoagulants of action ngqo awanako ukuvimbela isenzo sokuthintela. Oku kunokwenzeka xa kukho i-plasma cofactors. Umphambili phakathi kwabo ngu-antithrombin III.
Ezi ziyobisi zingezantsi kwiqela lalabo abathintekayo ekuthandeni ama-inhibitors, zibizwa ngokuba yi-antithrombin-dependent-inhibitors ye-III. Eli qela liquka ii-heparin eziphantsi kunye nephakathi.
- i-heparin sodium;
- i-heparin calcium;
- i-supraparin calcium;
- enoxaparin sodium;
- iparnaparin sodium
- i-reviparin sodium;
- i cybernyne;
- i-deltaparin sodium;
- hydrodium.
I-Heparin iyakwazi ukumisa umsebenzi wezinto ezithile ze-hemostasis. Okokuqala, oku kubhekisela kwikhallikrein, IXa, Xa, XIa, XIIa.
Uludwe lwamalungiselelo anticoagulants ngqo:
- ILoton 1000 (i-gel);
- I-Xarelto (iipilisi);
- I-Dolabene (i-gel);
- I-Heparin (iinjenge);
- I-Heparin Acrigel 1000 (i-gel);
- Venitane H (ukhilimu);
- Venolife;
- I-Thrombless (i-gel);
- Gepatrombin G (ioli).
AmaAnticoagulants of action ngqo
Ama-Anticoagulants of effect ngqo afaka iziyobisi ezonakalisa i-thrombin, eqinisweni, isebenze ngakumbi kunokumisa umsebenzi wayo. Eli qela le-anticoagulants liquka i-hirudin kunye neengqungquthela zayo ezidibeneyo, eziquka:
- girugen;
- girulog;
- argatroban;
- KUNYE.
Ukulungiswa kwangaphandle kwama-anticoagulants abizwa ngokuba yi-inhibitors ekhethiweyo okanye ngqo kwi-thrombin, kuba ayithembeki kwi-antithrombin III ngo-thrombin inhibitors.
Uluhlu lwamalungiselelo anticoagulants of action ngqo:
- IWarfarin Nycomed (amaphilisi);
- I-Phenylline (iipilisi).
Ukungqinelana
Ama-Anticoagulants anokuchasene, angabangela imiphumo emibi. Ngaloo ndlela, isilwanyana asikwazi ukulawulwa kubantu abanezifo nezifo ezilandelayo:
- izifo zesondlo sesisu esisisithambeko sokuphuma (umzekelo, isilonda se-peptic, i-bleeding hemorrhoids);
- izifo zesibindi, kubandakanywa nekartinal fibrosis yesibindi, i-hepatitis engapheliyo;
- urolithiasis;
- iimpawu zesifo sezintso;
- izifo zegazi, apho iindlela ze-hemostatic ziphulwa (umz., thrombocytopenic purpura);
- Ukusilela kwe-vitamin C-no-K;
- ukuxhathisa i-septic endocrine;
- isifo sofuba sepayipi.
Akwacetyiswa ukuba athathe amayeza kunye nee-antiticoagulants kubafazi abakhulelweyo.
Iziphumo eziPhakathi
Iziyobisi ze-Anticoagulant zinemiphumo emibi ekufuneka ziqwalaselwe ngaphambi kokuthatha iyeza. Ezi ziquka:
- ukungahambi ;
- intloko, umkhuhlane, i-asthenia;
- necrosis yolusu;
- umsebenzi wezintso eziphosakeleyo;
- isicongconi, ukubonakala kwezilonda emlonyeni, intlungu yesisu, inkathazo yengxaki, isifo sohudo, ukuhlanza nokuhlanza;
- kuthanda;
- ukubetha, ukukhawuleza, ukuguqa;
- phazamisa i intso.