17-OH-progesterone (i-17-hydroxyprogesterone, i-17-OGG, i-17-oh-progesterone) yi-precursor of hormones; uhlobo oluthile lwemveliso eqingqiweyo, apho i-hormone eyahlukeneyo (cortisol, estradiol, testosterone) yenziwa kwinkqubo enzima yokuguqulwa kwamanzi.
Izizathu zokunyuka kwe-17-OH-progesterone
Isizathu sokwandisa izinga le-17-oh-progesterone lidla ngokufumaneka kwiintlobo ze-adrenal or ovaries. Ukungasebenzi kwe-corréx ye-correnx ye-correnx (PDCN) yinto ebangela kakhulu ukwanda. I-adrenal dysfunction ihambelana nokusilela okanye ukungabikho kwe-enzyme ethile ye-21-hydroxylase, leyo, kunye ne-17-OH-progesterone, ibandakanyeka kwi-hormone cortisol. I-enzyme ayikho okanye ikhona ngexabiso elincinci, okwangoku njengokuba i-precursor ye-hormone 17-OH-progesterone iveliswa ngokukodwa kwiimeko eziqhelekileyo.
Kukho iifom ezimbini ze-VDKN: i-classic neyiyo-classic. I-Classical VDKN inqunywe kwiintsuku zokuqala / iinyanga zokuphila komntwana ngeempawu zangaphandle zeklinikhi ze-hermaphroditism. Ukuxilonga ifomu engeyiyo i-VDKN, njengomthetho, inokwenzeka kuphela kwintsholongwane (ngokubhekiselele kwimvelaphi: i-hirsutism, i-acne, i-acne, izitenxo zesigxina sokuya esikhathini) okanye ngexesha lokuzala (xa abafazi bejamelene neengxaki zokukhulelwa kunye nesisu).
Ukongezelela, uvavanyo lwegazi lokumisela izinga le-17-OH-progesterone lingabonisa ukugqithisa ngokwemimiselo ukuba:
- i-polycystic ovary syndrome (i-PCOS);
- izicubu ze-androgen ze-ovari okanye i-adrenal glands;
- ukugula okanye isifo se-Itenko-Cushing;
- hypothalamic syndrome;
- hyperprolactinemia ;
- nezinye izifo.
Iimpawu eziqhelekileyo ze-17-OH-progesterone
Iimimiselo ze-hormone zesini, ngokukodwa zabo zangaphambili-17-OH-progesterone, zinokuhluka kwiilebhu zezifo ezahlukeneyo. Kwi-diagnostic kufuneka ikhokelwe zizibonakaliso zereferensi yebhoratri ethile, zivame ukuboniswa kwiziphumo zohlalutyo.
Oogqirha abagunyazayo bakholelwa ukuba inqanaba eliphakamileyo elingu-17-OH-progesterone kumfazi ongeyena ukhulelwe ayifuni unyango kwaye luyinto eyahlukileyo. Umda wale nyukeko ngu-5 nmol / L = 150 ng / dl = 1.5 ng / l.
Oomama abakhulelweyo abenzi ukuhlolwa kwegazi kwi-17-OH-progesterone, ngexesha lokukhulelwa, inqanaba le-17-GPG landa, le nyaniso yinto evamile yokuphila. Kwaye ke oko kungenakuze kube nzima ukunika unyango kwizinga eliphakamileyo le-17-OH-progesterone ngexesha lokukhulelwa. Okukuphela kwezinto eziqhelekileyo ziimeko ze-classic VDKN.
Indlela yokunciphisa i-17-OH-progesterone?
Ukuba, ngokweziphumo zeemvavanyo, izinga le-17-OH-progesterone landa, kubaluleke kakhulu ukuqonda izizathu zokuphulwa ngaphambi kokuqala unyango. Unyango olumfama, olwenziwa yinyalo eninzi yoogqirha, ukuxhomekeka kwimigangatho yamandulo yonyango, ayinakuyicombulula ingxaki, kodwa iyancipha.
Ngoko, njani ukunciphisa izinga le-17-OH-progesterone? Kungakhathaliseki ukuba yintoni eyenza ukwanda, ibhinqa imiselwe ukusetyenziswa kwexesha elide leCOC - ukudibanisa ngomlomo (Jess, Yarin, Diana-3 okanye abanye). Ngoko ke, ukuba ibhinqa ifumene i-PCOS, kunye nokusebenza ngokuqhelekileyo kweengqungquthela ze-COC zonyango ngaphambi kokuba ukhulelwe, kudla ngokwaneleyo.
Ukuba imbangela yezinga eliphakamileyo le-17-OCG liyi-VDKN engekho i-classic, uvavanyo olunzulu lwe-endocrinologist kunye ne-genetics luyimfuneko,
Ukuphakanyiswa kwe-17-OH-progesterone kwininzi yamatyala kuyingozi yokungasebenzi. I-Dexamethasone, i-prednisolone okanye enye i-glucocorticosteroids kufuneka ithathwe kuphela kwimeko ye-PDCA engaqinisekisiweyo kwaye ihlinzeke kuphela ukuba ukukhulelwa kungenzi ngaphezu konyaka ongu-1, kwaye zonke ezinye izizathu ezibangelwa ukungabikho komntwana zingabandakanywa.