I-progesterone ye-17-OH yinto ekhoyo phakathi kwe-hormone ye-adrenal: i-glucocorticoids, i-estrogens kunye ne-androgens. I-progesterone i-progesterone ibhekisela kumahomoni wesilisa. Kwimizimba yabasetyhini, i-progesterone ye-17-OH iveliswa yi-adrenal and ovaries.
Umphumo we-17-OH progesterone emzimbeni womfazi
Kwintombazana emzimbeni, i-progesterone ye-17-OH ithintela ithuba lokukhulelwa kunye nexesha lokugaya, njengoko le hormone ithatha inxaxheba kwimisebenzi yokuzala. Ukongeza, amahomoni angamadoda emzimbeni wowesifazane udlala indima ekuqaleni kwentshukumo yobuntshantshi, anoxanduva lokuguqulwa kwamahomoni kwi-estrogens. Kwimizimba yabasetyhini, i-hormone yesilisa iveliswa ngaphantsi kweyendoda. Kodwa xa bekhuphuka ngaphezu kwezinga lomzimba, i-hyperandrogenia ikhula. Kwiimeko ezininzi, le ntsholongwane ifunyanwe ngaphambi okanye ngexesha lokukhulelwa.
Amaxabiso e-17-OH progesterone
Inqanaba le-17-OH progesterone liphakanyisiwe ekuqalekeni kokuzalwa komntwana, ingakumbi ukuba izalwe ngaphambi kwesikhathi. Emva kweveki yokuqala yobomi bomntwana, iqondo le-hormone liyehla kwaye lihlala lide lide ukuqala ukukhulelwa. Emva kokuqala kobuntwaba, inqanaba le-17-OH progesterone likhuphukela kwinqanaba le-hormone kubantu abadala:
- 0.2 - 2.3 ng / ml kumadoda;
- I-0.2 - 1.2 ng / ml kubasetyhini kwisigaba sesilandela;
- I-1.0 - 4.5 ng / ml kwabasetyhini kwisigaba esilandelayo;
- 2.0 - 12.0 ng / ml kwabasetyhini abakhulelweyo.
17-OH progesterone ephakamileyo - izizathu
Isizathu sokwandisa i-progesterone ye-17-OH ingaba kubakho ubuchopho njengale:
- i-congenital adrenal hyperplasia;
- ukusilela kwe-21-hydroxylase kunye ne-11-b hydroxylase;
- izicubu ze-ovari kunye nama-adrenal glands.
Amanqanaba aphakamileyo we-17-OH progesterone ziyabonwa ngexesha lokukhulelwa, okuyimimiselo yendalo. Ukuba i-progesterone ye-17-OH iphakanyiswe ngaphaya kwexesha lokukhulelwa, kufuneka udibane nogqirha ukuze ucebise kwaye usebenzise iimvavanyo zamahomoni.
17-OH progesterone ephakamileyo - iimpawu
Umgangatho ophezulu we-17-OH progesterone ungabangela iimpawu ezinjalo kubasetyhini:
- ukukhula kweenwele ezongezelelweyo kunye nokucutha;
- ukungabikho okanye ukungavumelekanga ukuya esikhathini;
- ukuphulwa kwezinga leshukela legazi;
- intsimbi .
Xa kungabikho unyango olwaneleyo, iimpawu ezinjalo ziyakwazi ukuqhubela phambili kwi-pathology enzima, njengale:
- ukuphulwa koxinzelelo lwe-insulin;
- isifo sikashukela;
- uxinzelelo lwegazi oluphezulu;
- kwandisa i-cholesterol;
- iingxaki ngentliziyo.
Ekubeni kwimeko yesifo se-polycystic ovaries, i-hormone 17-OH progesterone inganyuswa, ngoko ke, ekufumaneni esi sifo, kuyimfuneko ukupasa iimvavanyo ze-hormone.
Ukuphakanyiswa kweprogesterone ye-17-OH kunye ne-acne
Enye yeempawu zokwandisa i-progesterone ye-17-OH yintlaka okanye izibonda. Xa izinga le hormone liyancipha, i-symptomatology iyahamba. Ngoko ke, xa uphatha le ngxaki ye-dermatological, kuyimfuneko ukusetyenziswa nje kuphela kwindlela yokwenza izithambiso zendawo, kodwa kwakhona ulungelelanisa imvelaphi ye-hormonal.
Indlela yokunciphisa i-progesterone ye-17-OH?
Unyango olunophakamileyo lwe-17-OH progesterone lwenziwa ngamachiza e-hormonal. Umzekelo, dexamethasone okanye i-methylprednisolone. Xa uthatha la mayeza, kunokunyuka kwenyuka, kuba banamanzi. Azikho ezinye iziphumo zecala, kuba kunyango lwentlungu
Iskimu yokonyango kunye nokufumana iziyobisi kumiselwe ngugqirha kuxhomekeke kwizibonakaliso zeklinikhi zesi sifo, izigaba zokuhamba kwimihla. Umthamo wemihla kufuneka uhlulwe ngamanani amaninzi. Ixesha eliphakathi kokuthabatha iilisi kufuneka lilingane. Unokuthatha unyango emva kokutya, ukuba kukho iingxaki ngephepha lesisu. Ngexesha elifanelekileyo, kufuneka uthathe uvavanyo lwegazi, hlola izinga le-hormone kunye nokusebenza kwonyango.
Ngenxa yokungabikho komntwana ngaphambi kokuqala kokukhulelwa, inkqubo yokonyango inokuhlala kwiinyanga ezintathu ukuya ezintandathu.