Iimpawu ze-antibodies kwi-thyroglobulin - le yimi ipharamitha ephambili yokufumanisa izifo ze-thyroid, ezifana ne-atrophic autoimmune thyroiditis, isifo sikaHashimoto, i-goiter isifo esiyingozi.
Yintoni i-thyroglobulin?
Enyanisweni, i-thyroglobulin yi-glycoprotein, eyinxalenye ye-colloid ye-follicles ye-thyroid gland. Yenza umsebenzi wepropatide ekuqaliseni i-hormone ye-thyroid. Ngamazwi alula, i-thyroglobulin inokubonakala njengeprotheyini ekhoyo ngaphakathi kwintollicle ye-thyroid gland. Kwinkqubo yokufihla i-thyroglobulin i-hormone kwincinci encinci iwela egazini. Ngokutsho kwezilwanyana ezithile, iziza ezingaziwa, izizathu, ingaba yi-autoantigen, apho umzimba uqala ukuvelisa iziza-mzimba. Ama-antibodies, ukudibanisa ne-receptors ye-thyroglobulin, qalisa ukulinganisa isenzo se-hormone. Kule meko, isifo se-thyroid siqala ukubonelela umzimba ngamahomoni ngobuninzi, ukuphazamisa umthamo kunye nomsebenzi wentliziyo.
Ama-antibodies ku-thyroglobulin anqunywe ngenjongo yokuxilongwa kwangaphambili kwezifo ze-thyroid. Ngoko, banokuthi bangawavimba njani i-thyroglobulin, ngelixa bephazamisa ukusetyenziswa ngokuqhelekileyo kwama-hormone e-thyroid. Xa izikhuhlane ze-thyroglobulin zanda, zingabangela ukuvuvukala kwe-thyroid gland, i-hypothyroidism okanye, ngokuchaseneyo, ivuselela i-gland kwaye ibangele i- hyperthyroidism .
Ama-antibodies kwi-thyroglobulin - eqhelekileyo
Ama-antibodies kwi-thyroglobulin nayiphi na ixabiso le-U / ml kwibanga ukusuka ku-0 ukuya ku-18. Ngoko ke, kunokugqitywa ukuba i-antibodies kwi-thyroglobulin ayichithwanga.
Ama-antibodies kwi-thyroglobulin ngaphezu kwesiqhelo ingafumaneka kubantu abanempilo. Kule meko, kuma-antibodies kwi-thyroglobulin yanda kakhulu kunabesifazane, ngokukodwa abasetyhini abaneminyaka yobudala.
Indlela yokumisela inani le-antibodies kwi-thyroglobulin?
Isixa se-antibodies kwi-thyroglobulin emzimbeni senziwa ngokuhlalutya igazi kwi-vein vein. Olu hlalutyo lunikezelwa kwiqela elithile labantu, oko kukuthi:
- izigulane ezine-hypothyroidism (i-subclinical okanye ibonakala) ukuchonga imbangela yokubonakala kwayo;
- ukucacisa isizathu sokwanda kwenani le-thyroid;
- izigulane zithola i-interferon kunye neziyobisi ze-lithium, i-amiodarone. Izigulana apho izikhumbuza ze-thyroglobulin zinyuka, emva kokuthatha ezi zi yobisi zifumana isifo se-thyroid;
- i-fuddled, ukuba unina unama-antibodies kwi-thyroglobulin ngaphezu kwesiqhelo.
Ngenxa yokuhlalutya kwamagciwane okulwa ne-thyroglobulin kunokwenzeka ukuba uhlolisise imisebenzi yegciwane le-thyroid, ukuseka uhlobo lwesifo sayo kunye nezinga le-pathological process, ukubonakalisa izifo ezithandekayo.
Ama-antibodies ku-thyroglobulin angaphezu kwesiqhelo
Ukuba i-thyroglobulin inyukile, izizathu zokuba zikhona kwezi zifo zilandelayo:
- ukuxhatshazwa okanye i-thyroiditis engapheliyo (40-70% yezigulane), iHashimoto's thyroiditis (i-97% yezigulane);
- Isifo seMangcwaba (51% yezigulane);
- i-idiopathic myxedema (95% yezigulane);
- hypothyroidism (70% yezigulane);
- ukuhambisa i-goiter enobuhlungu (40% yezigulane);
- ezingaqaphelwanga i-thyroid ne-papillry carcinomas (i-nonmedullary carcinomas (i-15-30% yezigulane);
- ezinye izifo ezithintekayo, kuquka ne-anemia ephazamisayo.
Ukongezelela, ukuba i-thyroglobulin yanda kakhulu, le nto ingabonisa ubukho be-chromosomal engafanelekanga, ngokukodwa, i-Down syndrome okanye i-Turner syndrome.
Ubungakanani bokunciphisa izinga le-antibodies kwi-thyroglobulin emzimbeni ngokuthatha unyango kakhulu. Kwimichiza yanamhlanje, ukuba i-thyroglobulin yonyuka, unyango, ukwenzela ukuzisa izinga labo emzimbeni kwinto evamile. Ngoko, ukusebenzisa i-hemosorption, i-plasmapheresis, i-corticosteroids, "i-immunomodulator" ayinalutho kwaye, nokuba yingozi. Ukutyunjwa kwe-l-thyroxine akukwaso. Isifo ngokwawo sichazwe unyango, sichukunyiswe yinyuka emzimbeni wezinga le-antibodies kwi-thyroglobulin. Uvavanyo lwamagciwane olwenziwe kwi-thyroglobulin lusekwe kuphela ngenjongo yokuchaza okanye ukuphikisa ukuxilongwa, kwaye akukho ndlela yokuhlola ukuphumelela kwonyango. Umnxibelelwano uthi bafuna ukufumana imali kwisigulane, ngoko qaphela.