Abagcini bezithuthi zeCalcium

I i-i-calcium ions zibaluleke kakhulu ekuzibophelelweni kweenkqubo ezenzeka kwi-membrane yeselingi kunye neendlela zangaphakathi ze-intracellular. Oku kwenzeka ngeendlela ze-ion, apho iintlobo ezithile zeemodeli zeprotheni zivula indlela ye-i-calcium ions.

Indawo kunye nendima yeziteshi ze-ion

Ezi ziteshi, ngokwazo, zahlula zibe ziintlobo ezintathu:

• i-cytoplasmic;
• sakrolemalnye;
• intracellular.

Uninzi lweziteshi zekhalsiyamu zifumaneka kwisifo senhliziyo, kwaye ezisele zisemathanjeni emisipha ye-bronchi, isisu, isisu, isisu kunye neeplatelets.

Njengoko sele kukhankanywe, i i-calcium ion zithintela iinkqubo ze-metabolic emzimbeni, ezibangela ukuba:

• ukwanda kwindleko ye-oksijini;
• ukukhwabanisa kwesisu;
• ukunyuka okukhulu.

Ukunciphisa lo msebenzi kumachiza, iziyobisi eziseqeleni lama-blockers (BCC) kunye nekwabizwa ngokuba yi-block calcium.

Izibonakaliso zokusetyenziswa kunye nempembelelo yonyango yeBPC

Amalungiselelo okwelapha ama-block block calcium ayalelwe phambi kwezi zifo zilandelayo:

• xi nzelelo;
• angina pectoris ;
• ukungafezeki kolononari;
• Umxube we-angina kunye ne-bradycardia;
• tachycardia;
• intliziyo yeengxaki zesifo;
• ukuphazamiseka kwemisipha ye-cerebral;
• ukunqotshwa kwentliziyo ye-etiology engachazwanga;
• I-Raynaud's syndrome .

Ukongeza, i-BPC inokumiselwa izifo zesimiso se-nervous, i-allergies, i-bronchospasm kunye nezifo ezithile eziphazamisayo (isifo se-Alzheimer, isifo sengqondo soxinzelelo, utywala).

Inkqubo yesenzo se-calcium isithinteli somzimba ebangela umzimba:

• ukuphuka kwethambo epholileyo;
• ukuphuculwa kwegazi;
• ukunyaniseka kwenhliziyo;
• siphumo se diuretic;
• ukuhla kwejubane lokuhamba;
• ukwehla kwinqanaba lokuhlanganiswa kweplatelet kunye nokuphucula ukubunjwa kwegazi.

Ulwahlulo lweemveliso zonyango

Abaqambi beendlela zeCalcium banesigaba esithile kwaye bahlulwe ngo:

1. Iziphumo ezikhoyo ze-dihydropyridine. La machiza asekelwe kwi-nifepidine. Zinefuthe elikhulayo kwiinqanawa zengqondo (eKorinfar, Ardalat, Cordaflex, Lomir, Plendil, njl.).
2. Iziphumo zePhenylalkylamine. Iqela le-verapamil. Zichaphazela kakhulu iintliziyo zentliziyo, ukunciphisa isivumelwano. Impembelelo kwiinqanawa zibuthathaka (Isoptin, Prokorum, Finoptin).
3. Iziphumo zeBenzothiazinine. I diltiazem yeqela. Impembelelo yalezi yobisi iyancinci kuneleyo yeqela lokuqala, kodwa isatshalaliswa kwintliziyo kunye neempahla (Dilsem, Cardil).
4. Iziphumo zeDiphenylpyrazine. Iqela leCinnarizine. Ngokuqhelekileyo, iiCCB zimiselwe izilonda zemikhumbi yengqondo (Stugeron, Nomigrain).

Ukongeza, bonke abaxhasi bee-calcium ezisezantsi zihlukaniswe kwisizukulwana sokuqala nesesibili, kwaye izilungiselelo ze-dihydropyridine zinesithathu. Ukwahlula inqununu phakathi kwezizukulwana kukuphuculwa kweempawu zonyango kunye nokunciphisa imiphumo engathandekiyo emva kokuthatha iziyobisi. Kwakhona, izidakamizwa zesibini kunye nesithathu zenza izidakamizwa zinciphisa umthamo wemihla ngemihla, kwaye zifuneka zisetyenziswe kuphela kuma-1-2 ngamaxesha ngosuku. Kwababhali beendlela ze-calcium kwisizukulwana sesithathu ziziyobisi ezifana ne-Amlodipine, i-Latsidipin, i-Nimodipine.

Ukusetyenziswa kunye nokuchasene

Ukwamkelwa kwe-BPC kunokwenzeka kuphela emva kokubonisana ngokubanzi kunye ugqirha kunye noviwo. Kwimeko nganye, isilwanyana simiselwe ukuba sikwazi ukuvelisa umphumo ongcono wezokwelapha.

Isilwanyana ngasinye sinokuchasana ngokucacileyo, kodwa ngokuqhelekileyo, asinakunyuswa ukusetyenziswa xa:

• ukuhlasela kwentliziyo;
• tshutshiswa kwemizimba;
• ukukhulelwa, ngexesha lokutya;
• ebuntwaneni;
• ukunganyanzeliseki;
• isifo senhliziyo kunye neengxaki ezintso nasesibindi.