Ukwanda kwe-bilirubin - izizathu

I-Bilirubin i-pigment ye-bile, eyona mveliso esele isetshenziselwa ukutshatyalaliswa kweeseli zegazi ezibomvu zamandulo. Ngokuqhelekileyo, umntu omdala osempilweni yegazi iqulethe ixabiso elincinane (3,4 - 22,2 μmol / l), kunye nomlinganiselo othile we-urine ngohlobo lwe-urobilinogens (4 mg) imihla ngemihla.

Phantse i-96% ye-bilirubin egazini yinto engabonakaliyo ye-bilirubin engenawo amanzi kwaye inetyhefu, kuba Unokungena kalula kwiimbumba zeeseli kwaye uphazamise imisebenzi ebalulekileyo yeeseli. I-4% eseleyo i-bilirubin ngokuthe ngqo, i-soluble emanzini, ihlanjwe ngeentso kwaye igxothwe emcinini. Iyonke i-bilirubin yinqanaba eliqhelekileyo le-bilirubin ngqo kunye ngqo.

Kwimpilo ethile, umxholo we-bilirubin egazini, kwaye uqhubeka emvini, uyanda. Oku kubangela i-jaundice kunye nobumnyama bomchamo.

Iimbangela zezinga le-bilirubin ephakamileyo kubantu abadala

Makhe siqwalasele, zeziphi izizathu eziqhelekileyo okanye eziqhelekileyo ze-bilirubin kumzimba womntu onokunyuswa okanye ukwanda.

Izizathu zokunyuka kwe-bilirubin ngokuthe ngqo

Inqanaba le-bilirubin elichanekileyo egazini linyuka ngenxa yokuphulwa kwe-bile. Ngenxa yoko, i-bile ithunyelwa kwigazi, kungekhona kwisisu. Izizathu zezi zihlandlo zihlala zilandelayo:

• i-hepatitis ye-viral etiology kwisimo esibi (i-hepatitis A, B, ne-mononucleosis).
• i-hepatitis ye-bacterium etiology (leptospirosis, brucellosis);
• i-hepatitis engapheliyo;
• i-hepatitis;
• imishanguzo ye-hepatitis (ngenxa yonyango lwe-hormone, iziyobisi ezingekho-steroidal ezichasayo, iziyobisi ezichasene nezidakamizwa ezichasene nesifo sofuba);
• i-hepatitis enetyhefu (inetyhefu ngeentlanzi zefungal, izinto ezinobuthi ezinobungozi);
• umhlaza we gallbladder, isibindi okanye i-pancreas;
• cholelithiasis;
• i-cirrhosis yebhiliyari;
• i-syndromes yaseRotor, uDabin-Johnson.

Izizathu zokunyuka kwe-bilirubin engacacanga

Ukwanda kwimixholo ye-bilirubin engangqaliyo kunokudibana nokutshatyalaliswa ngokukhawuleza kweeseli ezibomvu zegazi okanye ukuphazanyiswa ekuqhutyweni kwe-bilirubin engacacileyo. Kufuneka ukuba uqaphele ukuba, ukususela oko i-bilirubin engangqaliyo emanzini ayichithe, nangona ukwanda okwenyuka kwinqanaba layo egazini, akukho nxaxhiso ekuhlalutheni umchamo. Ngoko, izizathu zezi zinto zinokuba:

• Inemia ye-hemolytic (isalle cell, spherocytic, nesferocytic, thallasemia, i-Marciyafawa-Michele isifo);
• i-hemolytic anemia (esichasene ne-rheumatoid arthritis, i-systemic lupus erythematosus, i-lymphocytic leukemia, i-lymphanganulmatosis, njl);
• i-hemolytic anemia (ehambisana ne-insulin, aspirin, levomycetin, levofloxacin, cephalosporins, njl);
• i-syndromes kaLucy-Driskol, Gilbert, Kriegler-Nayyar;
• izifo ezithathelwanayo (malariya, typhoid, sepsis);
• inetyhefu ye-hemolytic anemia ( ukutyhefuza ngamakhowa enetyhefu, iityhefu, ukubetha iinambuzane, iinyoka, ukutyhefuza ngamakhowe, ukukhokela, i-salts zethusi, njl.).

Izizathu zokunyusa i-bilirubin ekukhulelweni

Ukwanda kwe-bilirubin kudla ngokubonakalayo kwabasetyhini abakhulelweyo (i-jaundice ekukhulelwe). Izizathu zezi zinto zihlukaniswe ngamaqela amabini:

• ngenxa yokukhubazeka kokukhulelwa (ukuguqulwa kwamanzi amaninzi kwesibindi, gestosis, ukuhlanza ngokweqile, njl.);
• kubangelwa zizifo ezahlukahlukeneyo (i-hepatitis, i-hemolytic anemia, njl.).

Izizathu zokunyusa i-bilirubin emcini

Inqanaba elongeziweyo le-bilirubin kumchamo lubonakala kwizifo ezihamba kunye nomonakalo kwiiseli zesibindi iiseli:

• i hepatitis;
• i-cirrhosis yesibindi ;
• umonakalo wesibindi semetastatic;
• ukwenzakala kwesibindi, njl

Unyango lwe-bilirubin ephakamileyo

Ukuba iimvavanyo zibonisa ukuba i-bilirubin egazini okanye emcinini iphakanyisiwe, imigaqo yonyango iya kuxhomekeka kwizizathu zolu hlobo lwezilwanyana. Ngokuqhelekileyo, iindlela zokwelapha ziquka ukuthatha imithi kunye nokulungiswa kokutya.