Izilonda ze-adrenal zivelisa i- 17-OH-progesterone , ekwabafazi abajongene nomgaqo-moni wokujikeleza kwakhe. Umgangatho wayo awuhlali kwaye uhlala ujikeleza kuwo wonke umjikelezo: uhlala uphantsi ngaphambi kokuvuthwa, uphume kwaye uhlale uphakamileyo kwisiqingatha sesibini somjikelezo. Ukuba akukho khulelwa, ngokokuqala komjikelezo olandelayo, izinga le-17-OH-progesterone liwa.
Izizathu zokunyuka kwe-17-OH-progesterone
Ukukhulelwa ngenye yezizathu zokuba kungani i- 17-OH-progesterone iphakanyisiwe . Sekudlulileyo emva kokucoca kunye nokufakelwa, umgangatho wale hormone uqala ukuphakama.
Ukuba akukho ukukhulelwa, kukho ezinye izizathu, ngenxa yokuba i-17-oh-progesterone yanda, izifo ezinjenge-adrenal okanye i-ovarian tumors, i-congenital adrenal hyperplasia zifakiwe.
Iimpawu zokunyuka kwe-17-OH-progesterone
Ngokuqhelekileyo, izinga le-17-OH-progesterone:
- kumadoda ukusuka ku-0.2 ukuya ku-2.3 ng / ml;
- kwabasetyhini kwisigaba sokuqala somjikelezo ukususela kwi-0.2 ukuya kwi-1.2 ng / ml;
- kwisibini - ukusuka kwi-1.0 ukuya kwi-4.5 ng / ml;
- xa ukhulelwa kwi-2,0 ukuya kwi-12,0 ng / ml.
Kunokwenzeka ukukrokrela ukwanda kwinqanaba le-17-OH-progesterone kubasetyhini abanokubonakala kokukhula kweenwele emzimbeni kunye nokunciphisa. Ukwandisa izinga le-hormone likhokelela kwizihlandlo ezingaqhelekanga kumfazi okanye i-amenorrhea epheleleyo. Kwakhona, ukwanda kwe-17-OH-progesterone kubangela iingxaki zamanye amalungu kunye neenkqubo:
- Izinga lomshukela wegazi landa;
- kukho iingxaki zesikhumba kunye ne-acne;
- kunyusa uxinzelelo lwegazi kunye ne-cholesterol;
- kukho ukuphazamiseka emsebenzini wentliziyo yowesifazane nawuphi na ubudala.
Unyango lokunyuka kwe-17-OH-progesterone
Ukulungisa i-hormone ephakamileyo emva kokugqiba izinga lalo egazini linika imithi ye-hormonal (Prednisolone, Dexamethasone). Inkqubo yokonyango ithatha iinyanga ezintandathu, ukukhanselwa kwonyango akunakwenziwa ngokukhawuleza: idosi yamahomoni ihlala ilungiswe ngugqirha.