I-Antimulylerov i-hormone eyaziwa ngamayeza akudala kungekudala, kodwa ngoncedo lwakhe, bafunda ukufumanisa iziphazamiso ezithile zenkqubo yokuzala, ukugqiba ngesondo kunye nokuqikelela ukuqala kokuziyeka. Ngokuqhelekileyo, uhlalutyo lwe-AMG lunqunywe ngu-gynecologist-endocrinologist kwinqanaba lokuqala lokunyanga ukungabikho kwengqondo ngoncedo lokuncedisa ubuchwepheshe bokuzala (i-IVF, ukusabalalisa ngokwempahla). I-antimulylerov ephezulu i-hormone - uphawu oluphazamisayo, ukuthetha malunga nokuba khona kwezifo ezinzulu.
AMG kumadoda nabasetyhini
I-hormone yeAntimiller (AMG) yi-glycoprotein enxulumene nezinto zokukhula. Le nto iqala ukuphuhliswa ngexesha lokuphuhliswa kwamamoriki: kubafana abazayo - kwiiveki ezi-7-8, nakwiimantombazana ezizayo-malunga neveki ezi-32-36 zokukhulelwa.Yiyo hormone ejongene nokubunjwa kwenkqubo yokuzala: ngaphantsi kwefuthe le-AMG, i-embryo ye-asexual ine-involution (ukuhlaziywa okuqhubekayo) kwamadada ase-Mullerian - amaqhinga e-uterus kunye nama-fallopian tubes. Emva kokuzalwa kwamakhwenkwe emzimbeni, i-hormone iyaqhubeka iveliswa ngobuninzi beeseli ze-sertoli, kwaye ngokuqala kokushushula izinga le-hormone ye-antimulylerovoy liyancitshiswa kakhulu.
Ama-AMG amabhinqa ahlanganisela i-granulosa iiseli ze-ovary ukusuka kwi-trimester yesithathu yokukhulelwa ngaphambi kokuba kuqalwe umva. Xa kuthelekiswa namadoda, umxholo we-hormone ye-antimulylerovaya egazini lezesondo ezibuthathaka kakhulu kuncinci, kwaye emva kokuqala kobuntwaba, izinga le-AMH lancipha kancane kancane. Kutheni oku kwenzekayo?
Ngokuqhelekileyo, onke amabhinqa ekuzalweni anesitokisiso samaqanda, apho, ngokufika kokuqala kokuya esikhathini, ngokukhawuleza ugqityiwe ekupheleni komntu. Ngexesha lokuya esikhathini, iifolli ezininzi zikhula ngokukhawuleza kwi-ovary, enye yazo (ephezulu) iya kuba liqanda elivuthiweyo. Kwinqanaba elithile lokuhluthwa kweeseli zentsholongwane, i-hormone e-antimulyler ikhiqizwa elawula ukukhula kobugqwetha. Iingcali zenzululwazi ziye zafumanisa ukuba izinga le-AMG ngokuchanekileyo lihambelana nenani lamaqanda angabakho. Ngoko, ngoncedo lwe-ATM, umntu unokulinganisa indawo yokugcina i-ovarian yowesifazane kwaye ufumane izigqibo malunga nokuqala kokuphuma kwesisu.
I-Antimulylerov i-hormone iphakanyiswa - izizathu
Ngokuqhelekileyo izinga le-hormone ye-antimulylerovoy emadodeni ngowama-0,49-5,98 ng / ml, ngokwesini esilungileyo le nqondiso ifana ne-1-2.5 ng / ml. Ewe, kukho ukuphuka okuncinci kumgangatho oqhelekileyo. Ngokomzekelo, kwinqanaba le-horler le-Muller elingama-3 ng / mg, akufanele ukhathazeke. Nangona kunjalo, kwamanye amabhinqa antimulylerov hormone yanda kakhulu: ixabiso le-AGM lingaba ngu-5-6, kwaye ngamanye amaxesha 9 ng / ml. Yisiphi isizathu sezo zikhombisi?
Oogqirha bafumanisa ukuba kuma-hormone e-antimulylerov ngaphezu kwesiqhelo ihambelana nobukho bee-polycystic ovaries, kunye nesifo se-granulosa se-ovary. Ukongezelela, i-AMG ephezulu inokubonisa ukuba i-normogonadotropic endocrine (i-anovulatory) yokungabikho kwengqondo okanye ukulibaziseka ekuphuculweni ngokwesondo. AMG ngaphezu kwesiqhelo
Kwamadoda, i-hormone ye-antimuller eyandisiweyo iyathetha nge-cryptorchidism (indawo yokuvavanywa ngaphandle kwe-scrotum), ukulibaziseka ekuphuculweni ngokwesondo, ukusilela ekuveliseni i-androgens kunye nezinye iziphazamiso zenkqubo yokuzala.
Nangona kunjalo, akusoloko i-AMG ephakamileyo ibonisa ukufumaneka kwezifo. Ngamanye amaxesha isiguli sengqondo sinempembelelo enkulu kwimiphumo yocwaningo: ukunyamezela, izifo ezinzima, imidlalo enamandla inokuchaphazela izinga le-hormone egazini. Ngoko ke, iintsuku ezintathu ngaphambi kokuhlalutya, kuyimfuneko ukukholisa indlela yokuphila, ubalekele ukungabandezeleka nokuphepha imikhwa emibi xa kunokwenzeka.