Kuxilongo oluchanekileyo kwaye olufanelekileyo ngexesha loxolongo lwe- endometriosis , indlela yabaqhubi abaqhubekileyo isetyenziswa kakhulu. Ngokukodwa, onjalo umgcini we-CA-125 okanye i-antigen ye-antigen CA-125.
Inkcazo ye-CA-125 ye-endometriosis ibaluleke kakhulu, ngokukodwa kwisigaba sokuqala sokufumanisa izifo.
Umgangatho we-CA ngowama-125 we-endometriosis
Iqondo le-CA-125 ekupheleni kwe-endometriosis ligqitywe kwi-peritoneal fluid kunye ne-serum. Ukongezelela, ngokuqhelekileyo lo mmakishi womhlaza uhlala ekhona kwiisisu ze-endometrium, kunye nakwimicimbi ye-mucinous ne-serous ye-uterus. Ukuba izithintelo zemvelo aziphambuki, ngoko azingenanga kwigazi, kwaye ukwanda kwe-CA-125 akukwenzeki kwinqanaba lokukhanya kunye naphakathi kwe-endometriosis.
Ukuphakamisa izinga le-CA-125
Amanqanaba aphakamileyo ye-CA-125 ayinakubonwa kuphela kwi-endometriosis. Ingabonakaliswa kwakhona:
- ngexesha lokuya esikhathini;
- kwisithathu sokuqala sokukhulelwa;
- 1% yabasetyhini abasempilweni;
- kwizigulane ezingenayo i-neoplasms ezingalunganga;
- kwezinye izigulane ezine-neoplasia ezingekho gynecological neoplasia.
Ukuphakama kwe-CA-125 kwi-endometriosis
Ukuba i-CA-125 iphakanyisiwe ekupheleni kwe-endometriosis, ngoko, kuba le glycoprotein ihlanganiswa yii-derivatives ye-coelomic epithelium, ngummakishi womhlaza we-ovari . Ngoko ke, ukwanda kwinqanaba le-CA-125 ekupheleni kwe-endometriosis kunokubonisa ubungqina obubi kakhulu kwimpilo yowesifazane.
Ngokusekelwe kulo mbandela, kunokuqondakala ukuba ukucatshulwa kwesi sihlalutyo kuphazamisekile. Oogqirha bathi kukho kuma-80% amachiza okuyimfuneko ukuqhuba lonke uchungechunge lwezifundo ngaphambi kokubeka ukuxilongwa okuthembekileyo-endometriosis. Kodwa ngoxilongo olwenziwe kakade, inqanaba le-oncoprotein CA-125 lingaphumelela libe yinkqubo yokuphumelela kwonyango olumiselweyo.