I-Enam ibhekwa njengenye yezilwanyana ezinamandla kakhulu kunye nekhwalithi. Izibonakaliso zokusetyenziswa kwe-Enam zilinganiselwe, kuba i-remedy ithathwa njengeyona nto igxininiswe. Siyabulela kule nto ukuba le nkunkuma ayisebenzisi kuphela, kodwa iyasebenza.
Inkqubo yesenzo se-Enam
I-substance ebonakalayo ephambili ekulungiseleleni i-enalapril maleate. Leli candelo, ukungena emzimbeni, lichanekile kwaye lijika libe yinto esebenzayo ngokukhawuleza nangokukhawuleza-inalaprilat.
Ukongeza kwi-enalapril, u-Enam uqulethe ezi zinto zilandelayo:
- i-stearate ye-zinc;
- acidic;
- lactose anhydrous.
Isilwanyana senza ngokucacileyo: emva kokukhululwa kwe-enalaprilat, umzimba uvimbela ukuveliswa kwama-enzyme angiotensin. Ngenxa yolu, utshintsho lwe-angiotensin I kwi-angiotensin II lukhuselwe. Kwaye ngoko, ukunyanzeliswa kwendawo yonke yokunciphisa izitya kuyancipha, ukunyanzeliswa kwe-systolic kunye ne-diastolic kwehla. Inzuzo enkulu ka-Enam kukuba isicelo sawo asichaphazeli ukuphuhliswa kwe- tachycardia ye-reflex nganoma iyiphi indlela.
Uvelisa amayeza nezinye iziphumo:
- kuqinisa ukujikeleza kwegazi kwiintso;
- ivuselela iinkqubo zokucindezeleka;
- iinkqubo zocinezelo zecindezelo;
- kuncitshisa i-ventricular hypertrophy;
- kunciphisa kakhulu imfuno ye-myocardium kwi-oksijini;
- kuphucula imeko yesifo senhliziyo kunye ne-hypoxia.
Kubalulekile ukuba uqaphele ukuba ukungena kwe-Enam akuchaphazeli i-lipid ne-carbohydrates metabolism. Kwezinye iindidi zezigulane, eli nqaku lokukhetha amayeza linye yeyona nto ibaluleke kakhulu.
Kungakhathaliseki ukuba kuthathwa amacwecwe e-Enam, baqala ukusebenza emva kwemizuzu embalwa emva kokungena. Ukuxinwa kwe-enalaprilat emzimbeni kufinyelelwa kwiiyure ezintathu ukuya kwezine. Ukususwa kwezinto eziphambili ze-Enam zihambelana neentso. Umzimba uhlambulula emva kweeyure ezingama-11 ukuya kwe-12.
Izibonakaliso eziphambili zokusetyenziswa kwe-Enam
I-Enam yenye yezilwanyana ezinamandla iingcali azicebisi ukuba zisebenzise ukungalawulwa. Isalathiso esiphezulu sokusetyenziswa kwe-Enam - kwixinzelelo eliphezulu. Kungekudala, inani elikhulayo loogqirha liye lakhetha ukonyango lwexinzelelo lwangalo ngela mayeza. Amandla ka-Enam nawo alala eqinisweni yokuba ikuvumela ukuba ulwe neentlobo ezahlukeneyo zengxinzelelo, kuquka ezo zino-renovascular, kunye ne-blood pressure.
Isilwayo siye sazibonakalisa kunyango lwezifo ezifana:
- ukuhluleka kwentliziyo engapheliyo ;
- i-coronary ischemia.
Ukulwa nalezi zifo, i-Enam ingasetyenziswa njengonyango oluzimeleyo, kodwa ngokuqhelekileyo isilwanyana siba yinxalenye yonyango oludibeneyo.
Ukuziqhelanisa kuye kwaqinisekisa nokusebenza kwamachiza njengendlela yokukhusela izifo ezichazwe ngasentla.
Ukungqinelana nokusetyenziswa kwe-Enam
Ulwaphulo lokulawula ngomlomo lujoliswe. Umthamo ophezulu wemihla ngemihla ka-Enam ngowama-40 mg. Sebenzisa isicatshulwa sinconywa kanye ngemini, kungakhathaliseki ukuba kudla ukutya.
Njengamachiza amaninzi, u-Enam akafanelanga zonke izigulane. Isiyobisi esichaphazelekayo xa:
- i-aortic stenosis;
- khulelwa;
- kuncelisa;
- ukuphuhliswa kwe-angioedema kwimvelaphi yonyango kunye ne-ACE inhibitors;
- ukunyanzelwana komntu ngamnye kumacandelo okuqulunqa.
Ngokulumkisa kakhulu, u-Enam udinga abantu abanezifo ezinjalo:
- i-hypovolemia;
- ukuphulwa komnxeba wamanzi wetyuwa;
- i-stenosis yamarriyiti;
- isifo se-malabsorption ye-glucose-galactose.