Uhlalutyo lwamagciwane okulwa ne-thyroid peroxidase namhlanje lubonwa njengenye yezona ziwayo. Oogqirha bayayifakela kwizigulane zabo ngokuphindaphindiweyo. Ukuqonda oko kuthethwa yile nqondiso kwaye kutheni i-antibodies yokunyuka kwe-TPO, iyancipha xa ufumana iziphumo zovavanyo.
Ubani uhlalutyo lwamagciwane okuza ku-TPO?
Olu hlalutyo luthembeke ngakumbi kunezinye iinjongo ezininzi ezinokukwazi ukubona ukuba umzimba uvelisa isifo esizimele okanye cha. Ukuthetha ngokucacileyo, isibonakaliso se-antTPO sivumela ukuba sibonakalise, ukuba indlela yokuzivikela yintsholongwane yenzondelelo ngayo ngokumalunga nomzimba. I-TPO inoxanduva lokubunjwa kwe-iodine esebenzayo, engayinayo i-thyroglobulin. Kwaye amaninzi amachiza aya kubamba loo nto, ekhokelela ekunciphiseni kwe-hormone ye-thyroid.
Thumela zonke izigulane ukuhlolwa kwegazi lonke kwi-antibodies kwi-TPO ukuze ufumane ukuba abavuswanga, akuphosakeleyo. Uphononongo luboniswa kuphela phantsi kweemeko ezithile:
- Olutsha. Bavavanywa kwi-anti-TPO, ukuba ezi antibodies zifumaneka emzimbeni womama, okanye nge-postpartum thyroiditis.
- Izigulane ezine-thyroid gland.
- Abantu abafumana i-lithium kunye ne-interferon.
- Abantu abane-hypothyroidism. Uphando luyadingeka ukuze ufumane isizathu sesifo.
- Ngohlobo oluthile. Ukuba enye yezihlobo zineengxaki ngenxa yamanqwanqwa aphezulu e-TPO, isigulane ngokuzenzekelayo siwela kwiqela elijongene nobungozi kwaye lifuna iimviwo eziqhelekileyo.
- Emva kokuphuma kwesisu. Ngamanye amaxesha ukulahleka kwamathambo okanye ukuzalwa kwangaphambi kokuzalwa kwangoku kwenzeka ngenxa yokuba i-immune system ivelisa amanqindi aphilileyo.
Iyini inqanaba elongeziweyo lama-antibodies ku-TPO?
Ukubonakala kwe-antibodies kwi-TPO kubonisa ngokukodwa ukuba iiseli zegciwane le-thyroid ziya kutshabalaliswa ngokukhawuleza, kwaye inani elingekhoyo le-enzyme elifunekayo lenziwa emzimbeni. Kukho ezinye iinkcazo:
- Ukunyuka kwee-antibodies kwi-TPO kunokwenzeka ngokungaqhelekanga ngokuzimela: i- rheumatoid arthritis , i-diabetes mellitus, i-vasculitis ye-systemic kunye ne-lupus erythematosus.
- Ukuba i-antibodies kwi-TPO yanda kwabasetyhini abakhulelweyo, oku kuthetha ukuba umntwana unokuhlakulela i-hyperthyroidism ngamathuba angama-100%.
- Kwizigulane ezinama-antibodies ku-TPO ukwanda ngamaxesha angama-10, i-goiter enefuthe okanye i- Hashimoto's thyroiditis inokuthi ifumaneke .
- Inani elongeziweyo le-antibodies kwi-TPO ekuhlalutyweni okwenziwe emva kokuba ikhondo eliphambili lonyango libonisa ukungaphumeleli kwindlela yokonyulwa yonyango.
Maxa wambi ama-antibodies e-TPO anokwanda kwaye kungekho sizathu esicacileyo. Kungenzeka ngokukodwa kumzimba wesetyhini, kwaye uchazwa, njengommiselo, ngokutshintsha kwexesha elidala. Kule meko, le nto ibonwa njengesiqhelo. Kodwa kamva isigulane sisaphakanyiswa ngethuba elithile ukugcina ingcali.
Unyango lwee-antibodies eziphakamileyo kwi-TPO
Qinisekisa ukuba isibonakaliso sandile, into ephambili ngexesha. Ingxaki kukuba awukwazi ukuphilisa i-antibodies ephezulu kwi-TPO. Esi sibonakaliso sinokutshintshwa kuphela ukuba kukho into eyenziwe malunga nesifo esibangela ukuba sikhulise. Ukuba akukho nanyathelo ezithatyathwayo, isigulo singakhula ngaphandle kokuphazamiseka, kwaye inani le-antibodies elithile landa.
Isigaba sokuqala sonyango luvavanyo olupheleleyo ukufumanisa imbangela yenyuka kwinani lamathambo e-TBO. Oogqirha abaninzi kakhulu baye kwi-hormone yonyango yokutshintshwa. Ukusetyenziswa kwale ndlela kucebise kuphela xa kubangelwa ingxaki kwi-thyroid gland.