Izifo ze-neurological of migraine , ezibonakaliswa zizibilini ezinzima kunye neentlungu ezibuhlungu, ziqhelekile namhlanje. Xa unyango lwe-migraine, ukulungiselela amaqela ahlukeneyo asetyenziswayo, kwaye iyeza ngokwawo ijolise ekubanjweni kokuhlaselwa kwe-migraine nokukhusela (ukuthintela). Ukukhethwa kwezidakamizwa ezingabonakaliyo kwenzelwa izigulane ngabanye, kuthatha ingqalelo izinto ezinokubangela umdla, iimpawu zengqondo, ubukho be-pathologies ezihambelanayo, ubunzima beentlungu, njl njl.
Elinye lamachiza asebenzayo kakhulu ekugqibeleni iimpawu ze-migraine zilungiselelwe iqela lama-triptan. I-Triptans iyalathiswa iziyobisi ezingancedisi kuphela ukuphucula impawu ezibuhlungu kunye nolongezelelweyo lweempawu ze-migraine, kodwa zinciphisa ukuphindaphindiweyo kwezibamba.
Inkqubo yesenzo se-triptans
I-Triptans yonyango lwe-migraine, ezicetyiswayo kwizigulane ezixinzelelekileyo (ukuhlaselwa), kunye ne-degree edibeneyo yokungahlanjululwa. Ii-Triptans zivela kwi-serotonin, umlamli womnatha wesistim.
Indlela echanekileyo kunye epheleleyo yezenzo zamachiza ale qela ayizange ifundwe ngokwaneleyo ngoku. Kucingelwa ukuba la mayeza alwa nokuhlaselwa kwe-migraine, eneziphumo ezilandelayo eziphambili kwi-trigeminovascular system (i-neurons ye-nerve ye-core nerve kunye neenqwelo zangasese ezingenakulungiswa, ezizona zikhonkco ezibalulekileyo "ukuqaliswa" kokuhlaselwa):
- ukuvimbela isistim se-nergeminal nerve (i-neuroinhibitory effect);
- Ukunciphisa izitya ze-cerebrospinal kunye neempahla zeembrane zengqondo kunye nokunciphisa ukuhamba kwegazi kuzo (isenzo se-vasoconstrictor).
Kufuneka kuqatshelwe ukuba ii-triptans azichaphazeli eminye imithwalo yegazi yomzimba womntu.
Iintlobo zama-triptan
I-triptan yokuqala, eyaqala ukusetyenziswa kwimigraine, i-sumatriptan. Ukusetyenziswa kwesi sixhobo, isifundo sawo, izilingo zekliniki ziye zavumela ukuphucula imiphumo ye-triptans kunye nokuvelisa iziyobisi ezitsha, ezisebenzayo. Kuza kube yimhla, amayeza awaziwa kakhulu kwaye asetyenziswa ngokubanzi ukusuka kwiqela lama-triptans:
- Naratriptan;
- Frovatriptan;
- Eletriptan;
- Risotriptan;
- Zolmitriptan;
- Almotriptan nabanye.
Njengomthetho, i-triptans iyatholakala kwifomu yamacwecwe okulawula ngomlomo. Nangona kunjalo, kukho izilungiso zeli qela kwi-intranasal (iipraysal) kunye neencinki zangaphantsi (ii-injections), kwakunye ne-triptans ngendlela ye-suppositories yama-rectal.
Izixhobo ze-triptans
I-Tryptans kufuneka ithathwe ngokukhawuleza emva kokuqala kweempawu zokuqala zokuhlaselwa kwe-migraine. Iibhilethi azikwazi ukulunywa, kufuneka zihlanjwe ngaphantsi kwamanzi amaninzi. Njengomthetho, enye ithebhulethi inelungelo lokuyeka ukuhlaselwa. Ukuba intlungu ayifuni, ipilisi elandelayo ingathathwa emva kweeyure ezimbini. Qinisekisa umphumo wokusetyenziswa ngokubambene kweziyobisi zeli klasi kunye neziyobisi ezingekho-steroidal ezichasayo (ngesinconywa sogqirha).
Musa ukuthatha i-triptans ngexesha le-migraine aura . Xa kunesiphithiphithi esinzima kunye nokuhlanza, imizila ye-rectal, intranasal okanye ye-intramuscular of administration ikhethwa. I-Tryptans ayikwazi ukuthathwa ngokuphindaphindiweyo kwama-2 ngeveki. Awukwazi ukudibanisa nokusetyenziswa kwazo kunye namagciwane, i-antitivirals okanye i-antidepressants.
Ziyingozi kangakanani i-triptans?
Uphando lwezonyango lubonisa ukunyamezela ngokufanelekileyo kwama-triptans kwizigulane ezahlukeneyo.
I-Triptans iphikisana nakwiimeko:
- ngxinzelelo lwegazi;
- ukuphazamiseka okungapheliyo kokusabalalisa kwe-cerebral;
- ukuhluleka kwentliziyo;
- isicic heart disease;
- ukungazinzi okunzulu kunye nokungazinzi;
- ukukhulelwa kunye nokuhlaselwa.