Bisphosphonates kunyango lwe-osteoporosis

I-osteoporosis ithathwa njengenye yezona zifo eziqhelekileyo zesistim ye-musculoskeletal. Kwaye, ngokubhekiselele kwiindlela zokonyango, iingcali zayo kufuneka zicinge ngokuqhelekileyo ngokwaneleyo. Njengoko umkhuba ubonisile, i-bisphosphonates yokunyanga kwe-osteoporosis ifanelekile ngokunokwenzeka. Eli qela lamachiza laziwa ngokuba ngamayeza ukusuka kwi-XIX yekhulu leminyaka, kodwa kwakunokwenzeka ukufumana ukusasazwa ngokubanzi ngoku kutshanje.

Imithi-bisphosphonates

Iimpawu ezithile ze-bisphosphonates sele zisetyenzisiwe ukukhusela ukubola. Babesoloko besetyenziselwa kwiimveliso zeoli kunye namayeza. Namhlanje i-bisphosphonates ikwazi ukubeka isiseko seyeza zonyango. Zizosawoti ze-phosphorus, ezenza ukuba kuqaliswe ukuqala kweethambo zamathambo kunye nokuthintela ukutshatyalaliswa kwalo. Oko kukuthi, ezi zi yobisi zibonakala zenziwe ngokukhethekileyo kunyango lwe-osteoporosis.

Ukongezelela ekuqiniseni, i-bisphosphonates ivelise i-anesthetic and antitumor effect. Siyabulela oku, unyango lwe-bisphosphonate lusetyenziselwa iifractures kunye ne-hyperparathyroidism ephambili. Kwaye ukukwazi ukusebenza kwiiseli ezibi kwenza kube lula ukusebenzisa iziyobisi kwi-oncology, kunye ne-weakening of power.

Ziziphi izidakamizwa ze-bisphosphonate ezisetyenziselwa i-osteoporosis?

Zonke i-bisphosphonates zinokuhlulwa ngokweemeko zibe ngamaqela amakhulu amabini:

• equlethwe kwi-nitrogen;
• khu luleka kwi nitrogen.

Uluhlu lwamachiza athandwayo lubonakala kanje:

1. I-Bondronate imiselwe ukonyango kunye nokuthintela i-osteoporosis. Ngokungafani nezinye izidakamizwa ezifanayo, i-Bondronate ingathatyathwa nakwabesetyhini abafumana unyango lwe-hormone ngesikhatsi sokuphumula. Kwezinye iimeko, amayeza anikwe izigulane ezine- hypercalcemia .
2. I-bisphosphonate ye- Ethidronate sodium imiselwe ukunyuka kwe-osteoporosis kwaye ibonakalise ekwenzeni izifo eziye zavela kwimvelaphi ye-oncology.
3. I-Clodronic acid isetyenziselwa ukutshabalalisa i-macrophages. Eli chiza lenzeke kakuhle.
4. Amachiza I- Tiludronate imiselwe izigulane ezinamathambo athambileyo ukubuyisela ubungqina babo ngokukhawuleza kunokwenzeka.
5. I-Risedronate ivimbela iintlobo zomgudu kunye nentamo yentombi - eyona yingozi yingozi eyenzeka kubafazi be-postmenopausal.

Iimpawu zonyango lwe-bisphosphonate

Kubalulekile ukuqonda ukuba amathambo aqinisayo akuyona inkqubo ekhawulezayo. Kwaye nangona i-bisphosphonates yenza ngokukhawuleza, abazange bakwazi ukusombulula ingxaki iintsuku eziliqela. Ngoko, ukuqala unyango, isigulane kufuneka sizilungiselele ukuba ikhosi efanelekileyo iya kuhlala kunyaka. Ngokuqhelekileyo i-bisphosphonates ithatha iminyaka embalwa. Kodwa iziphumo zonyango ziyamangalisa ngokucokisekileyo kwazo.

Lawa mayeza anamandla kakhulu. Zonke izilungiso eziqulethe i-bisphosphonates aziyi kuchithwa kakuhle emzimbeni. Ngoko ke, ukwenzela ukuba le nyeza ibe ngcono kwaye ayiniki nayiphi na imiphumo emibi, kufuneka uhambelane nemithetho ethile kunye nezilumkiso:

1. Kungcono ukusela i-bisphosphonates kusasa ngesisu esingenalutho ubuncinane iyure nesiqingatha ngaphambi kokutya.
2. Kunconywa ukusela isibhengezi ngamanzi amaninzi. Sebenzisa nayiphi na enye imveliso (itiye, ijusi, ubisi) ayimfuneko kakhulu.
3. Kwithebhulethi kwakulula ukufika kwindawo ekuya kuyo, emva kokuyithatha ngokukhethekileyo kwiyure okanye kwisiqingatha ukuhlala okanye ukuma.

Ulungelelwaniso olufanelekileyo kunye nomlinganiselo walo kufuneka kukhethwe ngutitshala emva kokuhlolwa kokuqala kokuqala.