I-Gilbert's syndrome - iimpawu

I-Gilbert's syndrome (isifo sikaGilbert, isifo sekhaya esingekho i-hemolytic, i-cholemia elula yentsapho, i-hyperbilirubinemia yomgaqo-siseko) isifo esiza kuba nelifa elifanelekileyo, elibangelwa ukuguqulwa kwezinto eziphathekayo ezijongene nokunciphisa i-bilirubin kwisibindi. Esi sifo saqanjwa ngegama lesiGastro-gentroologist u-Augustine uNicolas Gilbert, owathi wachaza okokuqala ngo-1901. I-Gilbert's syndrome ngokuqhelekileyo ibonakalisa njengezinga eliphakamileyo le-bilirubin egazini, i-jaundice kunye nezinye iimpawu ezingezizo kwaye azifuneki unyango oluphuthumayo.

Iimpawu zeGilbert's Syndrome

Izimpawu eziphambili zesifo ziquka ezi zilandelayo:

1. I-Jaundice, xa kuqala ibona ukutshitshiswa kwe-icteric ye-sclera yelihlo (ukusuka phantse kungenakuphikiswa ukuchazwa). Kwiimeko ezinqabileyo, kunokubakho ukuhlaziywa kwesikhumba kunxantathu ye-nasolabial, iintendelezo, iintambo.
2. Ukuphazamiseka kwi-hypochondrium efanelekileyo, kwezinye iimeko, kunokunyuka okwenyuka kwesibindi.
3. Ubuthathaka kunye nokukhathala.
4. Kwezinye iimeko, isicupunu, iimpembelelo, iziphazamiso zesigxina, ukungahambisani nokutya ezithile.

Isizathu se-Gilbert's syndrome kukusilela kwisibindi se-enzyme ekhethekileyo (glucuronyltransferase), enoxanduva lokutshintshiselwa kwe-bilirubin. Ngenxa yoko, ukuphela kwe-30% yemali evamile ye-bile pigment ayixhatshazwa emzimbeni, kwaye ukugqithisa kwe-accumulates kwigazi, kubangela uphawu oluqhelekileyo lwezifo-jaundice.

Ukuxilongwa kweGilbert's Syndrome

Ukuxilongwa kwe-Gilbert's syndrome ngokuqhelekileyo kusekelwe kwiimvavanyo zegazi:

1. I-bilirubin epheleleyo kwi-syndrome yeGilbert isukela kwi-21 ukuya kwi-51 μmol / l, kodwa inokunyuka ibe ngu-85-140 i-μmol / l ngaphantsi kwefuthe lokusebenza ngokomzimba okanye nezinye izifo.
2. Isampula ngendlala. Ukubhekisela kwiimvavanyo ezithile (ezingaqhelekanga) kwi-syndrome yeGilbert. Ngokuchasene nokutya okanye ukuthotyelwa kwimihla yokutya e-calori-calorie ephantsi kwemihla emibini , i- bilirubin egazini liphuma ngo-50-100%. Imilinganiselo ye-bilirubin yenziwa kwisisu esingenalutho ngaphambi kokuvavanywa, emva koko emva kweentsuku ezimbini.
3. Umzekelo nge phenobarbital. Xa uthatha i-phenobarbital, izinga le-bilirubin egazini lehla ngokukhawuleza.

Indlela yokuhlala ne-Gilbert's syndrome?

Esi sifo ngokwaso asiqwalaselwa njengengozi kwaye ayidingi imfuneko yonyango oluthile. Nangona iqondo eliphakamileyo le-bilirubin egazini liqhubeka lonke ubomi, kodwa izinga eliyingozi alifikeleli kwinqanaba eliyingozi. Imiphumo yesigqirha sikaGilbert isoloko ibonakaliswe ukubonakaliswa kwangaphandle kunye nokuphazamiseka okuncinci, ngoko ke, ngaphezu kokutya, unyango lusebenzisa kuphela ukusebenzisa i-hepatoprotectors ukuphucula umsebenzi wesibindi. Kwaye (nakwiimeko ezinqabileyo, i-jaundice enzima) ukuthatha iziyobisi ezikunceda ukususa i-pigment engaphezu komzimba.

Ukongezelela, iimpawu zesifo asinasigxina kwaye ixesha elininzi linokuthi lingaqondakali, linyuka ngokunyameka komzimba, ukusetyenziswa kotywala, indlala, ubanda.

Into eyona nto ingabangela ingozi uGilbert's syndrome - kwiimeko ezinqabileyo, ukuba urhulumente aluhlonishwa kwaye udla ukuphazamiseka, kunceda ekuphuhliseni i-biliary tract ne- cholelithiasis .

Kwaye kufuneka kukhunjulwe ukuba esi sifo sifa, ngoko ke ukuba kukho imbali yomnye wabazali, kuyacetyiswa ukuba udibanise umzobo ngaphambi kokucwangcisa ukukhulelwa.