Inkqubo yegazi ye-coagulation iqhubeka kwiindidi eziliqela. Iyokuqala isakhiwo se-thromboplastin, okwesibini kukubunjwa kwe-thrombin, kwaye yesithathu yi-fibrinogenesis. Ukujikeleza okuqhelekileyo kwesigaba ngasinye kwigazi kufuneka kube yi-anticoagulant. Ukuba izinto ezingokwemvelo zanele, ngoko zixeliswa - iziyobisi zijojowe.
Iimpawu zokusetyenziswa kwee-antiplatelet agents
Antiagreganty - iziyobisi ezinefuthe eliphoxayo kwinkqubo yokucima igazi. Ngokutsho kwendlela yokubulala i-antiticoincidence, bahlula ngamaqela amabini:
- isenzo ngqo (i-heparinoids, i-heparin);
- isenzo esingathanga ngqo (iziphumo ze-phenylidandione kunye ne-oxicumarin).
Namhlanje, kukho i-agents antiplatelet zesityalo esitsha-ukungafani. Zineempembelelo zokuvimbela amandla ekuhlanganiswa kwamaplatelet.
Ukutyunjwa kwawo onke amaqela eziyobisi kunokuba ngabanye okanye ndawonye. Izibonakaliso eziphambili zokusetyenziswa kwe-anticoagulants zibonakaliso zegazi elixhatshazwayo (i-prethrombotic state) kunye nenkqubo ye-thrombotic yeendawo ezahlukileyo. Isigulane sinconywa ukuba sithathe la mayeza nangenkqubo ye-thrombotic kwinkqubo ye-coronary artery, njengoko le yindlela enye efanelekileyo yokukhusela i- infarction ebalulekileyo kunye nengqungquthela ye- myocardial .
Ukungqinelana nokusetyenziswa kwee-antiplatelet agents
Amagosa angama-antiplatelet anamhlanje akanakunikwa ukuba isigulane sinesifo:
- izixhobo zokugaya (nangona kwimeko ezinomdla wokuphuma);
- iinjongo kunye neempawu ze-hematuria;
- isibindi esinobungozi obukhulu bomsebenzi walo.
Akunconywa ukuba athathe amayeza eqela ukuba kukho iimpawu zesaphulelo sezintso, ukuphulwa kweendlela ze-haemostatic, ukusilela kwe-C-ne-K-vitamin kunye ne-heart syndrome.
Ezi zi yobisi zingabangela iziphumo zecala. Ziyabonakala ngokugqithiseleyo xa usebenzisa i-antiticoagulants yesenzo ngqo okanye esingangqali. Ukungafani kwamanye amazwe akukho miphumo emibi emzimbeni.
Iimiphumo eziqhelekileyo eziphambili ze-antiplatelet agents zi:
- iimpendulo ezithintekayo;
- intloko;
- iingxaki ezinzima;
- ukuphuma kwenye indawo.
Uluhlu lwee-antiplatelet agents
I-Anticoagulants yempembelelo ngqo ichaphazela ngokuthe ngqo imimandla yegazi ye-coagulation kwisiteshi se-vascular. Impembelelo yokwelapha kunye nejoyi e-intravenous iyenzeka ngokukhawuleza kwaye ihlala iiyure ezingama-6. Uluhlu lwee-antiplatelet agents zeli qela liquka:
- Heparinolds;
- Heparin;
- Arvin;
- I-calcium heparinate;
- I-Chondroitin sulfates A kunye noC.
Eyona ndlela isetyenziswa kakhulu yiHeparin. Ngokukhawuleza kukuvimbela ukubunjwa kwe-fibrin kwaye kuthintela ukuhlaselwa kweeplatelet zegazi.
Uluhlu lweziganeko ezichasene nezenzo ezingathanga ngqo ziquka:
- Dicoumarin;
- Cincumar;
- Na na
- Neodikumarin;
- Phenylin;
- Omefin.
Ziyakuvimbela ukuvala igazi kuphela emzimbeni. Isiphumo emva kokuba isicelo sifike kwiiyure ezingama-24-72 kwaye sihlala iintsuku eziliqela. Siyabulela kule propati ukuba iziyobisi zeli qela zilungele ukhathalelo lwexesha elide.
Ukwahlukana kwi-classified agents antiplatelet inendawo ekhethekileyo. Yonke into yokuba ayinomphumo omncinci kwimisebenzi ye-coagulation yegazi. Kodwa ngelo xesha bavala okanye bavimbele iipropati zokuxhaswa kwee-plates. Ngoko ke, ngokuhlanganisana namanye amachiza kunye nama-antiplatelet agents,
- Butadione;
- Papaverine ;
- Anturan;
- Indomethacin;
- Imizine;
- ICarbocromene;
- IParmedin.
Zonke ezi zingqinelaniyo kunye nokulumkisa kufuneka zibekwe kubantu abadala kunye nabadala.