Isilumachiza seMedformin siyiqela lee-antglycemic agents. Ngaphezulu kweminyaka engama-50 iMetformin isetyenziswe kunyango, ikakhulukazi iswekile sesifo sikashukela. Into esebenzayo yeziyobisi inefuthe elilandelayo emzimbeni:
- kunciphisa umxholo weshukela egazini ;
- kunciphisa ukutya;
- ukuqinisa i-lipolysis - ukusabela kwamafutha atshisa.
Imiqondiso yokusetyenziswa kweMetformin
I-Metformin ibangelwa zizifo ezilandelayo:
- isifo sikashukela sephepha 2, kubandakanywa kwiimeko ezihambisana nokukhuluphala;
- Isifo sikashukela sesifo sesifo sikashukela - isifo esinxulumene nengxaki ye-carbohydrates metabolism kwimvelaphi yeenguqu ze-hormone kwindoda ekhulelweyo yabasetyhini;
- I-syndrome ye-polycystic ovaries kubafazi abanophulaphula impendulo kwi-glucose.
Kwakhona, i-Metformin isetyenziswe njengeprophylactic yeemeko ezisongela ukuqala kwesifo sikashukela (prediabetes). Kwiminyaka yakutshanje, ulwazi lushicilelwe ukuba izidakamizwa ze-hypoglycemic zinciphisa umsebenzi weemveliso ezikhuthaza ukukhula kwezicubu ezinobungozi kwiintlanzi zamathambo kunye nezicubu ezihamba nesifo sikashukela. Oku kuqinisekiswa ngophando olwenziwa ngabaososayensi baseYunivesithi yaseMichigan (eU.SA) naseYunivesithi yaseSeoul (South Korea).
Ukungqinelana nokusetyenziswa kweMetformin
Kukho inani lokuchasene nokusetyenziswa kweMetmorphine. Ezi ziquka:
- umonakalo omkhulu ongapheliyo kwizitho ezibandakanyekayo kwi-metabolism (isibindi, izintso kunye nemiphunga);
- i-ketoacidosis - isifo esihambelana nokuphulwa kwe-carbon metabolism ngenxa yokuvelisa i-insulin;
- i-myocardial infarction;
- i-laktatsidoz - isifo, ngenxa yokuba umzimba uqokelela inani elikhulu le-lactic acid;
- iimeko ezinxulumene nokudambiswa kwamanzi (ngenxa yezifo, ukuxhatshazwa ngokwenyama) nokufumana kwiidlo eziphantsi kweekhalori;
- i-hypersensitive to the components of the drug.
Unonophelo olukhethekileyo iMetformin isetyenziselwa unyango lwabasetyhini abakhulelweyo nabaqeshisayo, kunye nezigulane ezingaphezulu kweminyaka engama-60.
I-Metformin yonyango yesifo sikashukela
Iipilisi ze-Metformin kufuneka zithathwe emva kokutya, umlinganiselo weziyobisi kuxhomekeke ekubeni i-insulin isetyenziselwa ukunyanga isigulane okanye cha. Kule meko, unikwe:
- Kubantu abangathathi i-insulini, iipilisi ezi-2 (1 g) kabini ngosuku ngosuku lokuqala lweentsuku ezintathu, ukusuka kwi-4 ukuya kweyesi-14-iipilisi ezi-2 ngamaxesha amathathu ngosuku. Ukususela ngomhla we-15, i-dosage incitshiswe ngokweengcomo zogqirha ngokuxhomekeka kwinqulatho ye-glucose kwi-biological fluids (umchamo kunye negazi).
- Ngokusetyenziswa kwexesha elifanayo kwe-insulin kwixabiso leeyunithi ezingama-40 ngosuku, i-Metformin isilinganiselo iyafana, kodwa umthamo we-insulin uyancipha kancane kancane ngeeyunithi ezine ngosuku.
- Kwinqanaba le-insulin ngaphezulu kwama-unit units ngosuku, kubandakanywa ne-Metformin, kuyimfuneko ukunciphisa umthamo we-insulin kuphela xa isiguli
phantsi kolawulo lwengonyango rhoqo, umzekelo, xa uhlala esibhedlele.
Umthamo we-Metformin ogqithiseleyo ungabangela i-hyperglycemia-ukwanda kwinqanaba le-glucose kunye nemeko enzima kakhulu - kwi-coma ephezulu kunye nemiphumo ebangela ukuba ibulawe. Kule nto, kubalulekile ukubeka iliso kwinqanaba le-glucose. Ukugqithisela kwinqanaba libonisa ukuba ukuthatha isiza kufuneka kuphazamiseke iintsuku eziliqela kwaye utshintshele kwi-insulin.
Nceda nceda! Ukunyangwa kwesifo sikashukela kunye ne-metformin ngaphandle kokusetyenziswa kwamanye amayeza ngexesha elifanayo kungabangela ubuthathaka nokulala . Oku kungenxa yokuba into esebenzayo inciphisa umxholo we-glycogen. Ukuphelisa imeko engathandekiyo kucetyiswa ukwenza injection ye-insulin.